Precision Medicine Beyond Tumor Sequencing
نویسندگان
چکیده
منابع مشابه
Clinical tumor sequencing: opportunities and challenges for precision cancer medicine.
Advances in tumor genome sequencing have enabled discovery of actionable alterations leading to novel therapies. Currently, there are approved targeted therapies across various tumors that can be matched to genomic alterations, such as point mutations, gene amplification, and translocations. Tools to detect these genomic alterations have emerged as a result of decreasing costs and improved thro...
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Rapid adoption of next generation sequencing (NGS) in genomic medicine has been driven by low cost, high throughput sequencing and rapid advances in our understanding of the genetic bases of human diseases. Today, the NGS method has dominated sequencing space in genomic research, and quickly entered clinical practice. Because unique features of NGS perfectly meet the clinical reality (need to d...
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AIM To understand how a cancer precision medicine tumor board (CPM-TB) made choices about return of results. MATERIALS & METHODS Observed CPM-TB deliberations and completed in-depth interviews with committee members. RESULTS Responding to complex evidence of ambiguous significance, deliberations of the CPM-TB were predicated on analytic validity and clinical utility. Members had concerns bo...
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ژورنال
عنوان ژورنال: Oncology Times
سال: 2020
ISSN: 0276-2234
DOI: 10.1097/01.cot.0000660216.95191.92